*PURPOSE: Kidney Transplant in recipients with Class 3 obesity( severely obese) has not been reported extensively. UK Transplant Registry data was interrogated to analyze outcomes of if any severely obese recipients had undergone renal transplantation since the year 2000. *METHODS: We harmonized the NHSBT UK Data to shortlist the renal transplants performed on Class 3 obese recipients in the UK from the years 2000-2019. The demographics report and survival analysis at 1,3 and 5 years post-transplant were data mined. Cox Regression was done to identify predictors of survival. SPSS 21 and Datatab were used for data analysis. *RESULTS: A total of N=163 recipients with Class 3 obesity underwent renal transplant since the year 2000 ( N=60 DBD, N= 48 DCD & N=55 Living Donor Kidney ). The median recipient age was 47 years - DBD, 51 years DCD, and 43 years LRD transplants. The odds of females getting renal transplants was OR 2.44( 1.14- 5.19) p=0.01 compared to males. Median eGFR at 3 months was 40, 38, and 46.5 for DBD, DCD, and LRD recipients, Median eGFR at 12 months was 42, 46.5, and 51.5 for DBD, DCD, and LRD recipients respectively. The median KDRI of transplanted kidneys was 1-07 and 1,08 for DBD & DCD kidneys respectively. The commonest cause of graft failure was acute rejection within the first 12 months of transplant. The technical failure rate was 1.8%. DCD Grafts were more likely to suffer rejection episode compared to others ( OR 2.25( 1.13-3.89) p=0.002. The Graft survival for DBD kidneys was 97%, 92% and 89% at 1,3 & 5 years, The Graft survival for DCD kidneys was 89%, 86%, and 76% at 1,3 & 5 years, The Graft survival for LRD kidneys was 98%, 95% and 86% at 1,3 & 5 years. ( Log Rank- 0.48). *CONCLUSIONS: Renal Transplantation for severely obese patients can be safely done with acceptable survival outcomes. Living donor kidneys have better outcomes but there is no statistical difference in graft outcomes from DCD versus DBD Kidneys. [

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]CITATION INFORMATION: Sharma H., Koufopoulos G., Bandara C., Ohia E., Mehra S., Sharma A. Kidney Transplantation in Class 3 Severely Obese Recipients is Safe.UK Renal Transplant Registry Data Analysis Since Year 2000 AJT, Volume 23, Issue 6, Supplement 1.

Hemant Sharma MD, MS, FICS

Royal Liverpool University Hospital

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